Aging is now recognized as the progressive disruption of multiple interconnected systems rather than a simple decline. As individuals age, the balance of redox reactions deteriorates, the immune system tends toward chronic low-grade inflammation, metabolic flexibility decreases, intestinal barrier integrity weakens, and neural networks become less adaptable. These alterations are encompassed within the “hallmarks of aging,” with inflammaging — the persistent low-grade inflammation that accumulates over time — emerging as a primary focus of nutritional interventions.
Sabinsa has developed a longevity-focused portfolio featuring branded ingredients that target multiple hallmarks simultaneously, ranging from the gut lumen to the brain.
C3 Reduct®
C3 Reduct® addresses the long-standing challenge of curcumin’s low and variable bioavailability by providing tetrahydrocurcuminoids (THCs), the reduced metabolites generated from curcumin in the body, directly. Work in Drosophila melanogaster has shown that THC can extend lifespan via the dFOXO and Sir2 sirtuin pathway, which is the same axis influenced by caloric restriction, with Sir2 deficient flies losing the benefit entirely. THCs from turmeric have been evaluated by EFSA as a Novel Food and are authorized for use in food supplements for adults at up to 140 mg per day, with no safety concerns identified at that intake.
Nigellin®
Nigellin® is a supercritical CO2 extract of Nigella sativa standardized to 5% thymoquinone (TQ). Reviews of TQ report that it downregulates NF κB and MAPK signaling, moderates matrix metalloproteinase activity relevant to tissue aging, supports mitochondrial antioxidant defenses such as superoxide dismutase and catalase, and promotes autophagic processes that help maintain proteostasis. In a randomized, double blind, placebo-controlled trial in subjects with allergic rhinitis, a TQ rich Nigella sativa oil containing Nigellin® produced significantly greater reductions in symptom scores and IgE levels than placebo, indicating clinically meaningful immune modulation.
Silbinol® and pTeroSol®
Silbinol® and pTeroSol® within Sabinsa’s pterocarpus platform provide complementary tools for metabolic and vascular aging. Silbinol® supplies pterostilbene from Pterocarpus marsupium, a naturally occurring analog of resveratrol with higher lipophilicity and metabolic stability. Pterostilbene has been shown to activate SIRT1, influence PGC 1α driven mitochondrial biogenesis, and support mitochondrial stress responses, with studies using Sabinsa’s material in diabetic animals reporting superior effects compared with resveratrol on blood glucose, insulin levels, and skeletal muscle contractile function. pTeroSol® is a water-soluble extract of Pterocarpus marsupium standardized to C glycosides such as pterocarposide and sabioside and has been clinically investigated for helping maintain healthy blood glucose and lipid parameters in adults with early type 2 diabetes.
Saberry®
Saberry®, a proprietary Emblica officinalis extract standardized to 10 % beta glucogallin, has been shown in vitro to inhibit alpha glucosidase, alpha amylase, and DPP 4, three enzymes directly involved in postprandial glycemic control. In a 90-day multicenter clinical trial in newly diagnosed type 2 diabetic subjects with dyslipidemia, Saberry® at 2 g per day significantly reduced fasting blood glucose, HbA1c, LDL cholesterol, and triglycerides, with some endpoints comparing favorably with metformin.
Tinofolin®
Tinofolin® is Sabinsa’s cognitive health ingredient based on Tinospora cordifolia. Clinical work with a standardized extract has shown improvements in verbal learning, logical memory, and recall in a placebo-controlled study, consistent with its traditional adaptogenic use and its proposed modulation of the HPA axis and stress response.
LactoSpore®
On the microbiome side, LactoSpore®(Bacillus coagulans MTCC 5856) is a spore forming probiotic with strong survival through gastric conditions and documented colonization and activity in the intestine. Clinical and in vitro data indicate that it can modulate inflammatory cytokines, support increases in butyrate producing genera, and improve both IBS symptoms and depression scores in a gut brain axis setting.
PoZibio®
PoZibio®, a postbiotic derived from heat inactivated Lactobacillus paracasei D3.5, has been shown in preclinical and early human work to enhance mucin production and strengthen the gut barrier, which is increasingly recognized as central to controlling systemic inflammation and aspects of aging.
ImmunoSpore®
ImmunoSpore® uses heat inactivated Bacillus coagulans MTCC 5856 to deliver cell wall components and metabolites that can support epithelial integrity and balanced immune responses in applications where live spores are not suitable, maintaining mechanistic continuity with LactoSpore®.
When seen together, these components beautifully showcase a systems biology approach to longevity, focusing on key areas like redox balance, immune health, mitochondrial function, blood sugar regulation, brain health, and gut barrier support through a coordinated strategy. For formulators and brand owners, Sabinsa’s portfolio offers a well-researched toolkit to create innovative healthy aging solutions that go beyond single-target methods, providing comprehensive support for the complex biology of aging.
