Advanced CBD Formulations: Personalized Approaches in Hypertension and Sex-Specific Absorption Insights
This review examines cannabidiol (CBD) as a non-psychotropic cannabinoid with growing clinical and nutraceutical relevance. It highlights regulatory-approved CBD medicines and focuses on novel lipid-based formulations designed to improve oral bioavailability. Results from two randomized crossover studies demonstrate enhanced absorption, sex-dependent pharmacokinetics, and CYP450 genotype – related metabolic differences using a lipophilic CBD formulation. Improved cardiovascular outcomes and minimal adverse effects were observed. The findings emphasize the importance of personalized dosing, advanced delivery systems, and improved professional education on CBD use.
Author: Ana Batinić, M.pharm, PhD in Toxycology