Search
Close this search box.
Search
Close this search box.
Search
Close this search box.

News in the Gut-Brain Area

The increased focus on healthy aging – to live longer and stay healthy – drives consumers to seek ways to improve their health in general but also in specific health areas like digestive, immune and mental health. Probi® strengthens the Gut-Brain offering with new study in older adults.

Inflammaging, a newer term used to describe chronic inflammation that accompanies aging, was investigated in a recently published study. The UN has estimated that the population aged 65 years and older will continue to rise during the coming years, eventually doubling by 20501. With an increased older population, the demands on the healthcare system will ultimately increase, driving higher costs and longer wait times. The increase in expected lifespan can also be seen on an individual and marketing level, as more and more people are actively searching for ways to improve their longevity and healthy aging.

The new study is the 4th clinical study performed on the proprietary strain Lactiplantibacillus plantarum HEAL9 (HEAL9™) investigating its benefits in the Gut-Brain area. The study included older adults (>70 years) with chronic low-grade inflammation and investigated the anti-inflammatory effects of HEAL9, alone or in combination with berries. The results showed significantly decreased levels of inflammation, which could play a role in chronic conditions such as cardiovascular disease, diabetes and Alzheimer’s disease.

Intake of HEAL9 was shown to decrease inflammatory levels, with significantly decreased calprotectin overall compared to placebo. Significantly fewer participants had elevated calprotectin at the study’s end compared to placebo. There was also a tendency of decreased CRP within the HEAL9 group not seen with placebo, and of reduced pro-inflammatory marker TNF-alpha in the HEAL9 group compared to placebo. Cognitive assessment using the Trail Making Test also showed improvement with HEAL9 consumption. The combination of HEAL9 with berries seemed not to be more beneficial for improving low-grade inflammation than the HEAL9 alone.

“With the findings of this 4th clinical study, showing the benefits of our HEAL9 strain in the gut-brain area, Probi is cementing our status as pioneers also within this growing new health area for probiotics. The new data obtained in older adults follows a previous study, published in 2023, in which the HEAL9 strain was shown to support and improve cognitive performance, as well as memory, mood and sleep in adults at the age of 21-52 years. Supporting cognitive functions and healthy aging is relevant for everyone who wants to live healthier lives for a longer time, and we are confident that our Probi Sensia concept is relevant for many age groups seeking to lay the foundation for better health later in life” says Anita Johansen, CEO Probi AB.

The study “Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial” was published in the journal Probiotics and Antimicrobial Proteins (June 2024) and can be found here: LINK .

1 Nations U (2020) World population ageing 2019 (st/esa/ser. a/444). Department of Economic and Social Affairs PD, editor New York, USA 2020

Share the Post:

Related Posts

Symrise celebrates 150 shades of innovation with the milestone sun protection

As part of its “150 shades of innovation” campaign to mark the 150th anniversary of
the first patent of founding father Wilhelm Haarmann, Symrise is commemorating its
milestones. Symrise will put the second highlight on the pioneering work, processes,
and ingredients from their Sun Protection business. The Holzminden-based company
has been shaping this industry for over 70 years by leading research and delivering
game-changing product innovations in the skin and sun care space.

Read More

Fragrance Allergens and Their INCI Names in the Cosmetics

The updated naming conventions for essential oils and extracts of popular plant species to minimize discrepancies and prevent errors between the names of extracts derived from different parts of the same plant.

Author: Gordana Gorinšek, MSc in Phytomedicine, Expert Cosmetic Safety Assessor, Expert Regulatory Affairs Consultant

Read More